Nakashima M, Ishikawa K, Fugiwara A, Shu K, Fukushima Y, Okamoto M, Tsukamoto H, Kouwaki T, Oshiumi H.
miR-451a levels rather than human papillomavirus vaccine administration is associated with severity of murine experimental autoimmune encephalomyelitis.
Scientific Reports 11: 9369, 2021
Tsukamoto H, Komohara Y, Oshiumi H.
The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets.
Human Cell doi: 10.1007/s13577-021-00514-2 (Online ahead of print)
Tsukamoto H, Kouwaki T, Oshiumi H.
Aging-associated extracellular vesicles contain Immune regulatory microRNAs alleviating hyperinflammatory state and immune dysfunction in the elderly
iScience 2020 23: 101520
Recent advances and contradictions in the study of the individual roles of ubiquitin ligases that regulate RIG-I-like receptor-mediated antiviral innate immune responses
Frontiers in immunology 2020 11:1296
Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells
J Biol. Chem. 294: 18969-18979. 2019
Wang G, Kouwaki T, Okamoto M, Oshiumi H
Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
Miyashita M, Ishikawa K, Fukushima Y, Kouwaki T, Nakamura K, Oshiumi H.
Immune-regulatory microRNA expression levels within circulating extracellular vesicles correspond with the appearance of local symptoms after seasonal flue vaccination.
PLoS One 14: e0219510. 2019
MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrphage and dendritic cell responses to influenza whole-virus vaccine.
J. Biol. Chem. 293: 18585-18600. 2018
Tsukamoto H, Fujieda K, Miyashita A, Fukushima S, Ikeda T, Kubo Y, Senju S, Ihn H, Nishimura Y, Oshiumi H
Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor environment.
Cancer Research 78: 5011-5022. 2018
Fukushima Y, Okamoto M, Ishikawa K, Kouwaki T, Tsukamoto H, Oshiumi H
Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells.
BBRC 500: 744-750, 2018
Takashima K, Oshiumi H, Matsumoto M, Seya T
TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells
BBRC 499: 985-991, 2018
Okamoto M, Kouwaki T, Fukushima Y, Oshiumi H
Regulation of RIG-I Activation by K63-Linked Polyubiquitination
Frontiers in Immunology 8:1942, 2018
Takashima K, Oshiumi H, Matsumoto M, Seya T
DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochodrial Antiviral Signaling Protein function in Conjunction with HSP70.
J. Innate Immunity 10: 44-55, 2018
Tsukamoto H, Fujieda K, Senju S, Ikeda T, Oshiumi H, Nishimura Y
Immune-suppressive effects of IL-6 on T-cell-mediated anti-tumor immunity.
Cancer Science 10: 44-55, 2018
Fujikura D, Muramatsu D, Toyomane K, Chiba S, Daito T, Iwai A, Kouwaki T, Okamoto M, Higashi H, Kida H, Oshiumi H
Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection.
J. Biochem 163: 31-38, 2018
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.
Scientific Reports 7: 11905, 2017
Okamoto M, Tsukamoto H, Kouwaki T, Seya T, Oshiumi H
Recognition of viral RNA by pattern recognition receptors in the induction of innate immunity and excessive inflammation during respiratory viral infections.
Viral Immunology 30: 408-420, 2017
Takaki H, Oshiumi H, Shingai M, Matsumoto M, Seya T.
Development of mouse models for analysis of human virus infections
Microbiology and Immunology 61: 107-113, 2017
Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, and Oshiumi H
Extracellular vesicles deliver host and virus RNA and regulate innate immune resonse
International Journal of Molecular Sciences 18: 666, 2017
Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nkano H, Tanaka Y, Iwai K, and Inoue JI.
HTLV-1 Tax induces Formation of the Acitive Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains
PLoS Pathog. 13: e1006162, 2017
Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.
Oncotarget 7: 68149-68193, 2016
Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, and Seya T.
STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.
BBRC 478: 1764-1771, 2016
Funami K, Matsumoto M, Oshiumi H, Obuse C, and Seya T.
The dataset of proteins specifically interacted with activated TICAM-1.
Data Brief 8: 697-699, 2016
Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, and Seya T.
Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy. Oncoimmunology 5: e1188244, 2016
Kouwaki T, Fukushima Y, Daito T, Sanada T, Yamamoto N, Mifsud EJ, Leong CR, Tsukiyama-Kohara K, Kohara M, Matsumoto M, Seya T, and Oshiumi H. Extracellular vesicles including exosomes regulate innate immune response to hepatitis B virus infection. Frontiers in Immunology 7: 335 eCollection 2016
Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, Matsumoto M, Kasahara M, Seya T.
Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine
myeloid cells. BMC Immunol. 17(1):9. 2016
Oshiumi H, Kouwaki T, Seya T.
Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response. Frontiers in Immunology 7: 200 eCollection 2016
Oshiumi H, Mifsud EJ, Daito T. Links between recognition and degradation of cytoplasmic viral RNA in innate immune response. Reviews in Medical Virology: 26: 90-101, 2016
*Oshiumi H, Miyashita M, Okamoto M, Morioka Y, Okabe M, Seya T. DDX60 is involved in RIG-I-dependent and –independent antiviral responses and its function is attenuated by virus-induced EGF receptor activation. Cell Reports: 11: 1193-1207. 2015 *Corresponding author
Takashima K, *Oshiumi H, Takaki H, Matsumoto M, Seya T. RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response. Cell Reports 11: 192-200. 2015. *Corresponding author
Oshiumi H*, Miyashita M, Matsumoto M, and Seya T. A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses. PLoS Pathogens 9, e1003533 (2013)
Miyashita M, Oshiumi H*, Matsumoto M, and Seya T. DDX60, a DExD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor mediated signaing. Mol. Cell. Biol. 31, 3802-3819 (2011) *Corresponding author
Oshiumi H*, Miyashita M, Inoue N, Okabe M, Matsumoto M, and Seya T. The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Cell Host & Microbe 8, 496-509 (2010)
Oshiumi H, Matsumoto M, Hatakeyama S, Seya T. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. J Biol Chem. 284, 807-817 (2009)
Hayase A, Takagi M, Miyazaki T, Oshiumi H, Shinohara M, and Shinohara A. A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1. Cell 119, 927-940 (2004)
Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T* TICAM-2: a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 278, 49751-49762 (2003)
Oshiumi H, Matsumoto M, Funami K, Akazawa T, and Seya T*
TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nature Immunology 4, 161-167 (2003)
Oshiumi H, Tsujita T, Shida K, Matsumoto M, Ikeo K, and Seya T*
Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish Fugu rubripes genome. Immunogenetics 54, 791-800 (2003)
Usui T#, Ohta T#, Oshiumi H#, Tomizawa J, Ogawa H, and Ogawa T..
Complex Formation and Functional Versatility of Mre11 of Budding Yeast in Recombination. Cell 95, 705-716 (1998) #These authors contributed equally to this work.
TEL : 096-373-5135（研究室）
Department of Immunology,
Graduate School of Medical Sciences,
Faculty of Life Sciences,
School of Medicine
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