研究業績(熊本大学免疫学講座)

最近の論文

2019年

Wang G, Kouwaki T, Mugikura K, Okamoto M, Takaki H, Funami K, Seya T, Oshiumi H. 

Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells

J Biol. Chem. 294: 18969-18979. 2019

 

Wang G, Kouwaki T, Okamoto M, Oshiumi H

Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I

Cell Reports 28: 1961-1970. 2019

 

Miyashita M, Ishikawa K, Fukushima Y, Kouwaki T, Nakamura K, Oshiumi H.

Immune-regulatory microRNA expression levels within circulating extracellular vesicles correspond with the appearance of local symptoms after seasonal flue vaccination.

PLoS One 14: e0219510. 2019

2018年

Okamoto M, Fukushima Y, Kouwaki T, Daito T, Kohara M, Kida H, Oshiumi H

MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrphage and dendritic cell responses to influenza whole-virus vaccine.

J. Biol. Chem. 293: 18585-18600. 2018

 

Tsukamoto H, Fujieda K, Miyashita A, Fukushima S, Ikeda T, Kubo Y, Senju S, Ihn H, Nishimura Y, Oshiumi H

Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor environment. 

Cancer Research 78: 5011-5022. 2018

 

Fukushima Y, Okamoto M, Ishikawa K, Kouwaki T, Tsukamoto H, Oshiumi H

Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells. 

BBRC 500: 744-750, 2018

 

Takashima K, Oshiumi H, Matsumoto M, Seya T

TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells

BBRC 499: 985-991, 2018

 

Okamoto M, Kouwaki T, Fukushima Y, Oshiumi H

Regulation of RIG-I Activation by K63-Linked Polyubiquitination

Frontiers in Immunology 8:1942, 2018

 

Takashima K, Oshiumi H, Matsumoto M, Seya T

DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochodrial Antiviral Signaling Protein function in Conjunction with HSP70.

J. Innate Immunity 10: 44-55, 2018

 

Tsukamoto H, Fujieda K, Senju S, Ikeda T, Oshiumi H, Nishimura Y

Immune-suppressive effects of IL-6 on T-cell-mediated anti-tumor immunity.

Cancer Science  10: 44-55, 2018

 

Fujikura D, Muramatsu D, Toyomane K, Chiba S, Daito T, Iwai A, Kouwaki TOkamoto M, Higashi H, Kida H, Oshiumi H

Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection.

J. Biochem 163: 31-38, 2018

2017年

Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, Oshiumi H

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.

Scientific Reports 7: 11905, 2017

 

Okamoto M, Tsukamoto H, Kouwaki T, Seya T, Oshiumi H

Recognition of viral RNA by pattern recognition receptors in the induction of innate immunity and excessive inflammation during respiratory viral infections.

Viral Immunology 30: 408-420, 2017

 

Takaki H, Oshiumi H, Shingai M, Matsumoto M, Seya T.

Development of mouse models for analysis of human virus infections

Microbiology and Immunology 61: 107-113, 2017

 

Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, and Oshiumi H

Extracellular vesicles deliver host and virus RNA and regulate innate immune resonse

International Journal of Molecular Sciences 18: 666, 2017

 

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nkano H, Tanaka Y, Iwai K, and Inoue JI.

HTLV-1 Tax induces Formation of the Acitive Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

PLoS Pathog. 13: e1006162, 2017 

2016年

Leong CR, Funami K, Oshiumi H, Mangao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K, and Seya T.

Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.

Oncotarget 7: 68149-68193, 2016

 

Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, and Seya T.

STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.

BBRC 478: 1764-1771, 2016

 

Funami K, Matsumoto M, Oshiumi H, Obuse C, and Seya T.

The dataset of proteins specifically interacted with activated TICAM-1.

Data Brief 8: 697-699, 2016

 

Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, and Seya T.

Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy. Oncoimmunology 5: e1188244, 2016

 

Kouwaki T, Fukushima Y, Daito T, Sanada T, Yamamoto N, Mifsud EJ, Leong CR, Tsukiyama-Kohara K, Kohara M, Matsumoto M, Seya T, and Oshiumi H. Extracellular vesicles including exosomes regulate innate immune response to hepatitis B virus infection. Frontiers in Immunology 7: 335 eCollection 2016 

 

Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, Matsumoto M, Kasahara M, Seya T.

Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells. BMC Immunol. 17(1):9. 2016

Oshiumi H, Kouwaki T, Seya T.

Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response. Frontiers in Immunology 7: 200 eCollection 2016 

 

 

Oshiumi H, Mifsud EJ, Daito T. Links between recognition and degradation of cytoplasmic viral RNA in innate immune response. Reviews in Medical Virology: 26: 90-101, 2016 

2015年以前の主な論文

*Oshiumi H, Miyashita M, Okamoto M, Morioka Y, Okabe M, Seya T. DDX60 is involved in RIG-I-dependent and –independent antiviral responses and its function is attenuated by virus-induced EGF receptor activation. Cell Reports: 11: 1193-1207. 2015 *Corresponding author

 

Takashima K, *Oshiumi H, Takaki H, Matsumoto M, Seya T. RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response. Cell Reports 11: 192-200. 2015. *Corresponding author

 

Oshiumi H*, Miyashita M, Matsumoto M, and Seya T.  A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses.  PLoS Pathogens 9, e1003533 (2013)

 

Miyashita M, Oshiumi H*, Matsumoto M, and Seya T.  DDX60, a DExD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor mediated signaing. Mol. Cell. Biol. 31, 3802-3819 (2011) *Corresponding author

  

Oshiumi H*, Miyashita M, Inoue N, Okabe M, Matsumoto M, and Seya T. The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Cell Host & Microbe 8, 496-509 (2010)

 

Oshiumi H, Matsumoto M, Hatakeyama S, Seya T. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. J Biol Chem. 284, 807-817 (2009)

  

Hayase A, Takagi M, Miyazaki T, Oshiumi H, Shinohara M, and Shinohara A. A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1. Cell 119, 927-940 (2004)

 

Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T* TICAM-2: a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 278, 49751-49762 (2003) 

 

Oshiumi H, Matsumoto M, Funami K, Akazawa T, and Seya T* 

TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.  Nature Immunology 4, 161-167 (2003)

 

Oshiumi H, Tsujita T, Shida K, Matsumoto M, Ikeo K, and Seya T* 

Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish Fugu rubripes genome.  Immunogenetics  54, 791-800 (2003)

 

Usui T#, Ohta T#, Oshiumi H#, Tomizawa J, Ogawa H, and Ogawa T..

Complex Formation and Functional Versatility of Mre11 of Budding Yeast in Recombination.  Cell 95, 705-716 (1998) #These authors contributed equally to this work.

 

 

 

 

2016年以前の個人の業績

押海

塚本(粟井)