業績　(粟井（塚本））

1.      Hirayama M., Tomita Y., Yuno A., Tsukamoto H., Senju S., Imamura Y., Sayem M., Irie A., Yoshitake Y., Fukuma D., Shinohara M., Hamada A., Jono H., Yuba E., Kono K., Yoshida K., Tsunoda T., Nakayama H., and Nishimura Y.  An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.  Oncoimmunology  2016 (In press).

 

2.      Sayem M., Tomita Y., Yuno A., Hirayama M., Irie A., Tsukamoto H., Senju S., Yuba E., Yoshikawa T., Kono K., Nakatsura T., and Nishimura Y.  Identification of Glypican-3-derived long peptides activating both CD8⁺ and CD4⁺ T-cells; prolonged overall survival in cancer patients with Th cell response. Oncoimmunology  5: e1062209, 2016.

 

3.      Tsukamoto H., Senju S., Matsumura K., Swain, S.L., and Nishimura Y.  IL-6-mediated environmental conditioning of defective Th1 differentiation dampens anti-tumor immune responses in old age.  Nat. Commun., 6: 6702 doi: 10.1038/ncomms7702, 2015.

 

4.      Motoshima T., Komohara Y., Horlad H., Tsukamoto H., Fujita M., Saito Y., Tanoue K., Kasejima Y., Sugiyama Y., Kawano Y., Nishimura Y., Takeya M., Eto M.  CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.  

Oncol Lett doi:10.3892/ol.2016.4132, 2015

 

5.      Ikeda T., Hirata S., Takamatsu K., Haruta M., Tsukamoto H., Ito T., Uchino M., Ando Y., Nagafuchi S., Nishimura Y., Senju S.  Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.  PLoS One  9: e115198, 2014.

 

6.      Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M. Irie A., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Daigo Y., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.  Identification of immunogenic LY6K long peptide encompassing both CD4⁺ and CD8⁺ T-cell epitopes and eliciting CD4⁺ T-cell immunity in patients with malignant disease.  Oncoimmunology  3: e28100, 2014.

 

7.      Tomita Y., Yuno A., Tsukamoto H., Senju S., Yoshimura S., Osawa R., Kuroda Y., Hirayama M., Hamada A., Jono H., Irie A., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.  Identification of CDCA1 long peptides bearing both CD4⁺ and CD8⁺ T-cell epitopes: CDCA1-specific CD4⁺ T-cell immunity in cancer patients.　　Int. J. Cancer  134, 352–366, 2014.

 

8.      Yatsuda J., Irie A., Harada K., Michibata Y., Tsukamoto H., Senju S., Tomita Y., Yuno A., Hirayama M., Sayem M. A., Takeda N., Shibuya I., Sogo S., Fujiki F., Sugiyama H., Eto M. and Nishimura Y.; Establishment of HLA-DR4 transgenic mice for the identification of CD4⁺ T cell epitopes of tumor-associated antigens.　　PLoS One  8: e84908, 2013.

 

9.      Tsukamoto H., Nishikata R., Senju S., and Nishimura Y.  Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression.　　Cancer. Immunol. Res.  1: 64-76, 2013.

 

10.   Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M., Irie A., Kawahara K., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.  Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.  Clin. Cancer Res.  15: 4508-4520, 2013.

 

11.   Horlad H., Fujiwara Y., Takemura K., Ohnishi K., Ikeda T., Tsukamoto H., Mizuta H., Nishimura Y., Takeya M., Komohara Y.  Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells.  Mol. Nutr. Food Res.  57: 1046-1054, 2013.

 

12.   Tsukamoto H., Huston G.E., Dibble J., Duso D.K. and Swain S.L.  Bim limits the accumulation of naïve CD4 T cells with age-related defects by regulating their lifespan.  J. Immunol.  185: 4535-4544, 2010.

 

13.   Tsukamoto H., Clise-Dwyer K., Huston G.E., Duso, D.K., Buck A.L., Haynes L. and Swain S.L.  Age-associated increase in lifespan of naïve CD4 T cells contributes to T cell homeostasis but facilitates development of functional defects.
Proc. Natl. Acad. Sci. U S A.  106: 18333-18338, 2009.

 

14.   Tsukamoto H., Irie A., Senju S., Hatzopoulos A.K., Wojnowski L. and Nishimura Y.　B-Raf-mediated signaling pathway regulates T cell development.  Eur. J. Immunol.  38: 518-527, 2008. (Citation Index: 10, Impact Factor: 4.034)

 

15.   Irie A., Harada K., Tsukamoto H., Kim J-R., Araki N. and Nishimura Y.  Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells.  Int. Immunol.  18: 1737-1747, 2006

 

16.   Tsukamoto H., Irie A., Kim J-R., Chen Y-Z., Takeshita K., and Nishimura Y.  TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone.  Eur. J. Immunol.  36: 1926-1937, 2006.  

 

17.   Kim, J-R., Irie, A., Tsukamoto, H., and Nishimura, Y. A role of kinase inactive ZAP-70 in altered peptide ligand stimulated T cell activation.  Biochem. Biophys. Res. Comm.  341: 19-27, 2006.

 

18.   Hosaka S., Nakatsura T., Tsukamoto H., Hatayama T., Baba H. and Nishimura Y.　　Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.  Cancer Sci.  97: 623-632, 2006.

 

19.   Yoshitake Y., Nakatsura T., Monji M., Senju S., Matsuyoshi H., Tsukamoto H., Hosaka S., Komori H., Fukuma D., Ikuta Y., Katagiri T., Furukawa Y., Ito H., Shinohara M., Nakamura Y. and Nishimura Y.  Proliferation potential-related protein, an ideal esophageal cancer antigen for immnotherapy, identified using cDNA microarray analysis.  Clinical Cancer Research  10: 6437-6448, 2004.　

 

20.   Tsukamoto H., Irie A. and Nishimura Y.  B-Raf contributes to sustained extracellular signal-regulated kinase activation that regulates IL-2 production through the T cell receptor.  J. Biol. Chem.  279: 48457-48465, 2004.　

21.   Nishimura Y., Chen Y-Z., Uemura Y., Tanaka Y., Tsukamoto H., kanai T., Yokomizo H., Yun C., Matsuoka T., Irie A. and Matsushita S.  Degenerate recognition and response of human CD4+ Th cell clones: implications for basic and applied immunology.  Mol. Immunol.  40: 1089-1094, 2004.　

 

22.   A, Irie, Y-Z, Chen, H, Tsukamoto, T, Jotsuka, M, Masuda, and Y, Nishimura. Unique T-cell proliferation associated with PKCμ activation and impaired Zap-70 phosphorylation in recognition of overexpressed HLA-DR/partially agonistic peptide complexes.  Eur. J. Immunol.  33: 1497-1507, 2003

 

23.   Uemura, Y., Senju, S., Maenaka, K., Iwai, L.K., Fujii, S., Tabata, H., Tsukamoto, H., Hirata, S., Chen, Y-Z. and Nishimura, Y.  Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for GAD65 specific TCRs.  J. Immunol.  170: 947-960, 2003.　

 

24.   Yamane, T., Kunisada, T., Tsukamoto, H., Yamazaki, H., Niwa H., Takada, S. and Hayashi, S.  Wnt signaling regulates hemopoiesis through stromal cells. J. lmmunol.  167: 765-772, 2001.

1.      塚本博丈　「IL-6と老年における免疫応答の低下」  臨床免疫・アレルギー科, 科学評論社　(In press)　2016.

 

2.      塚本博丈　「Myeloid-derived suppressor cells (MDSC)によるTh1細胞の抑制機序」  臨床免疫・アレルギー科, 科学評論社　61: 428-435, 2014.

 

3.      塚本博丈, 西村泰治　 「腫瘍免疫の最前線：　T細胞を介した抗腫瘍免疫応答」  実験医学9月増刊, 羊土社　31: 32-39, 2013.

 

4.      塚本博丈, 西村泰治　 「炎症・免疫分野とノーベル賞」  炎症と免疫, 先端医学社 18: 192-196, 2010.

 

5.      塚本博丈, 西村泰治 　「抗原認識のメカニズム」  Medicina, 医学書院 43 (6),　2006.

 

6.      塚本博丈, 西村泰治  CLIP置換型インバリアント鎖遺伝子を利用したペプチド/MHC-II複合体発現細胞システムの構築　　Medical Science Digest, ニュ−サイエンス社, 31 (5): 5-6, 2005.

 

7.      塚本博丈, 西村泰治 　MHCによる抗原提示  バイオ研究マスターシリーズ 免疫学集中マスタ−, 羊土社, 84-92, 2005.

 

5207. 2014

 

Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T. PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo. Cancer Immunol Res. 3(8):902-914. 2015

受賞：

2014年        日本免疫学会　Tadamitsu Kishimoto International Travel Award

2013年        日本がん免疫学会　若手研究奨励賞

2002年        日本免疫学会　Melcher’s Travel Award

 

招待講演：

「加齢に伴うCD4陽性T細胞の機能不全と、それに伴う抗腫瘍免疫応答の低下」シンポジウム　“がんの進展制御における老化の役割”　第４７回　日本癌学会、2015年10月8日、名古屋

2014年-現在   　科学研究費補助金　基盤研究（C）

2015年        　　公益財団法人　高松宮妃癌研究基金　研究助成

2014年        　　公益財団法人　武田科学振興財団　医学系研究奨励

2012-2013年     科学研究費補助金　若手研究（B）

2012年          　公益財団法人　安田記念医学財団　癌研究助成

2011年          　公益財団法人　興和生命科学振興財団　研究助成

2010-2011年     科学研究費補助金　若手研究（B）

2010年         　 公益財団法人　武田科学振興財団　医学系研究奨励

2007年          　公益財団法人　上原記念生命科学財団　フェローシップ