研究業績(押海）

Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, Matsumoto M, Kasahara M, Seya T. Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells. BMC Immunol. 17(1):9. 2016

*Oshiumi H, Miyashita M, Okamoto M, Morioka Y, Okabe M, Seya T. DDX60 is involved in RIG-I-dependent and –independent antiviral responses and its function is attenuated by virus-induced EGF receptor activation. Cell Reports: 11: 1193-1207. 2015 *Corresponding author

 

Takashima K, *Oshiumi H, Takaki H, Matsumoto M, Seya T.　RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response. Cell Reports 11: 192-200. 2015. *Corresponding author

 

Sato H, Oshiumi H, Takaki H, Hikono H, Seya T. Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog. Microbiol Immunol. 59(10): 633-640. 2015

 

Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T. Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2. J Immunol. 195(9): 4456-4465. 2015

 

Nakai M, Oshiumi H, Funami K, Okamoto M, Matsumoto M, Seya T, Sakamoto N. Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV). Sensors (Basel). 15(10): 27160-27173. 2015

 

Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K, Seya T. 　A MAVS/TICAM-1-independent interferon-induction pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model. J Innate Immun. 7: 47-58. 2015

 

Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, Matsumoto M, Seya T. INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells. J Immunol. 193(10):5199-5207. 2014

 

Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T. PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo. Cancer Immunol Res. 3(8):902-914. 2015

 

Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, Matsumoto M, Seya T.　INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.　J Immunol. 193: 5199-5207 (2014)

 

Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T. IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection J Immunol. 192: 2770-2777 (2014)

 

Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T. MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150 Tg mouse bone marrow-derived dendritic cells. Mol. Immunol. 57: 100-110 (2014)

 

Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T. Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models. J Innate Immun. 6: 293-305 (2014)

 

Suzuki T, Oshiumi H*, Miyashita M, Aly HH, Matsumoto M, Seya T. Cell-type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA PLoS One 8: e83649 (2013)

 

Takaki H, Takeda M, Tahara M, Shigai M, Oshiumi H, Matsumoto M, Seya T. The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model. J Immunol. 191: 4740-4747 (2013)

 

Oshiumi H*, Miyashita M, Matsumoto M, and Seya T.  A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses.  PLoS Pathogens 9, e1003533 (2013)

 

Azuma M, Ebihara T, Oshiumi H, Matsumoto M, Seya T. Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells. Oncoimmunology 1, 581-592 (2012)

 

Shime H, Matsumoto M, Oshiumi H, Tanaka S, Nakane A, Iwakura Y, Tahara H, Inoue N, Seya T. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci U S A 109, 2066-2071 (2012)

 

Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S. The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice. J Virol. 86, 185-194 (2012)

 

Oshiumi H, Okamoto M, Fujii K, Kawanishi , Matsumoto M, Koike S, and Seya T. The TLR3-TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. J. Immunol 187, 5320-5327 (2011)

 

Miyashita M, Oshiumi H*, Matsumoto M, and Seya T.  DDX60, a DExD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor mediated signaing. Mol. Cell. Biol.　31, 3802-3819 (2011)

 

Aly HH, Oshiumi H, Shime H, Matsumoto M, Wakita T, Shimotohno K, Seya T. Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV). PLoS One 6, e21284 (2011)

 

Takaki H, Watanabe Y, Shingai M, Oshiumi H, Matsumoto M, Seya T. Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential. Mol Immunol. 48, 497-504 (2011)

 

Ehira N, Oshiumi H*, Matsumoto M, Kondo T, Asaka M, Seya T. An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma. J Exp Clin Cancer Res. 29, 135 (2010)

 

Oshiumi H*, Miyashita M, Inoue N, Okabe M, Matsumoto M, and Seya T. The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Cell Host & Microbe 8, 496-509 (2010)

 

Oshiumi H, Ikeda M, Matsumoto M, Watanabe A, Takeuci O, Akira S, Kato N, Shimotohno K, Seyat T.  Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.  PLos One 5, e14258 (2010)

 

Ebihara T, Azuma, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T. Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.  J. Exp. Med. 207, 2675-2687 (2010)

 

 

Zhu Z^#, Mori S^#, Oshiumi H^#, Matsuzaki K, Shinohara M, Shinohara A. Cyclin-dependent kinase promotes formation of the synaptonemal complex in yeast meiosis. Genes Cells 15, 1036-1050 (2010) ^#These authors contributed equally to this work.

 

Tatematsu M, Ishii A, Oshiumi H, Horiuchi M, Inagaki F, Seya T, Matsumoto M. A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation. J Biol Chem. 285, 20128-20136 (2010)

 

 

Kasamatsu J, Oshiumi H, Matsumoto M, Kasahara M, Seya T. Phylogenetic and expression analysis of lamprey toll-like receptors. Dev Comp Immunol. 34, 855-865 (2010)

 

Oshiumi H, Sakai K, Matsumoto M, Seya T. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential. Eur J Immunol. 40, 940-948 (2010)

 

Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y. Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet. 6, e1000828 (2010)

 

Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T. Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway. Mol Immunol. 47, 1283-1291 (2010)

 

Takaki H, Oshiumi H, Sasai M, Kwanishi T, Matsumoto M, and Seya T. Oligomerized Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule-1 in the cytoplasm recruits nuclear adenovirus 5 E1A-binding protein to enhance NF-kB activation and type I IFN induction. Eur J.Immunology 39, 3469-3476 (2009)

 

Yasukawa K, Oshiumi H, Takeda M, Ishihara N, Yanagi Y, Seya T, Kawabata S, Koshiba T. Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci Signal. 2, ra47 (2009)

 

Oshiumi H, Suzuki Y, Matsumoto M, Seya T. Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis. Immunogenetics. 61, 371-384 (2009)

 

Oshiumi H, Matsumoto M, Hatakeyama S, Seya T. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. J Biol Chem. 284, 807-817 (2009)

 

Matsuo A^#, Oshiumi H^#, Tsujita T, Mitani H, Kasai H, Yoshimizu M, Matsumoto M, Seya T. Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses. J Immunol. 181, 3474-3485 (2008)  ^#These authors contributed equally to this work.

 

Funami K, Sasai M, Oshiumi H, Seya T, Matsumoto M. Homo-oligomerization is essential for Toll/IL-1 receptor domain-containing adaptor molecule-1-mediated NF-kappa B and IRF-3 activation. J Biol Chem. 283, 18283-18291 (2008)

 

Higuchi M, Matsuo A, Shingai M, Shida K, Ishii A, Funami K, Suzuki Y, Oshiumi H, Matsumoto M, Seya T. Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily. Dev Comp Immunol. 32, 147-155 (2008)

 

Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M* Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J Immunol. 2007 Nov 15;179(10):6867-6872

 

Shiratori I, Suzuki Y, Oshiumi H, Begum NA, Ebihara T, Matsumoto M, Hazeki K, Kodama K, Kashiwazaki Y, Seya T. Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model. Cancer Sci. 98, 1936-1942 (2007)

 

Oshiumi H, Shida K, Goitsuka R, Kimura Y, Katoh J, Ohba S, Tamaki Y, Hattori T, Yamada N, Inoue N, Matsumoto M, Mizuno S, Seya T. Regulator of complement activation (RCA) locus in chicken: identification of chicken RCA gene cluster and functional RCA proteins.  J Immunol. 175 (3), 1724-34. (2005)

 

Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, Seya T. NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation.  J Immunol. 174, 27-30 (2005)

 

Hayase A, Takagi M, Miyazaki T, Oshiumi H, Shinohara M, and Shinohara A. A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1. Cell 119, 927-940 (2004)

 

Tsujita T, Tsukada H, Nakao M, Oshiumi H, Matsumoto M, Seya T. Sensing bacterial flagellin by membrane and soluble orthologues of toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss). J Biol Chem. 279, 48588-48597 (2004) [IF, 4.6; citation, 92]

 

Kimura Y, Inoue N, Fukui A, Oshiumi H, Matsumoto M, Nonaka M, Kuratani S, Fujita T, Nonaka M, Seya T. A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3.　J Immunol. 173, 1118-1128 (2004)

 

Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T* The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.  Int Immunol. 16, 1143-1154 (2004)

 

Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T* TICAM-2: a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 278, 49751-49762 (2003)

 

Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, Yamamoto A, Seya T*  Subcellular localization of toll-like receptor 3 in human dendritic cells.  J Immunol. 171, 3154-3162 (2003)

 

Oshiumi H, Matsumoto M, Funami K, Akazawa T, and Seya T* 

TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.  Nature Immunology 4, 161-167 (2003)

 

Oshiumi H, Tsujita T, Shida K, Matsumoto M, Ikeo K, and Seya T* 

Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish Fugu rubripes genome.  Immunogenetics  54, 791-800 (2003)

 

Usui T^#, Ohta T^#, Oshiumi H^#, Tomizawa J, Ogawa H, and Ogawa T..

Complex Formation and Functional Versatility of Mre11 of Budding Yeast in Recombination.  Cell 95, 705-716 (1998) ^#These authors contributed equally to this work.

 

 

Oshiumi H, Kouwaki T, Seya T. Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response. Frontiers in Immunology 7: 200 eCollection 2016

 

Oshiumi H, Mifsud EJ, Daito T. Links between recognition and degradation of cytoplasmic viral RNA in innate immune response. Reviews in Medical Virology: 26: 90-101, 2016

 

Takaki H, Oshiumi H, Matsumoto M, Seya T Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models. Int J Biochem Cell Biol. 53: 329-333 (2014)

 

Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T. Multi-step regulation of interferon induction by hepatitis C virus. Arch Immunol Ther Exp (Warsz). 61, 127-38 (2013)

 

Matsumoto M, Funami K, Oshiumi H, Seya T. Toll-IL-1-receptor-containing adaptor molecule-1: a signaling adaptor linking innate immunity to adaptive immunity. Prog Mol Biol Transl Sci 117: 487-510 (2013)

 

Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M. TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis. Oncoimmunology. 1, 917-923 (2012)

 

Oshiumi H, Matsumoto M, and Seya T. Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I. J Biochem. 151, 5-11. (2012)

Matsumoto M, Oshiumi H, Seya T. Antiviral responses induced by the TLR3 pathway  REVIEWS IN MEDICAL VIROLOGY   21, 67-77 (2011)

 

Seya T, Shime H, Ebihara T, Oshiumi H, Matsumoto M. Pattern recognition receptors of innate immunity and their application to tumor immunotherapy. CANCER SCIENCE   101, 313-320(2010)

 

Seya T, Matsumoto M, Ebihara T, Oshiumi H. Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing. Immunol Rev. 227, 44-53 (2009)

 

Oshiumi H*, Matsuo A., Matsumoto M. and Seya T. Pan-Vertebrate Toll-like Receptors During Evolution. Current Genomics  9, 488-483 (2008)

 

Seya T*, Oshiumi H, Sasai M, Akazawa T, Matsumoto M. TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons.　Int J Biochem Cell Biol. 37, 524-529 (2005)

 

Matsumoto M*, Funami K, Oshiumi H, Seya T.       Toll-Like Receptor 3: A Link between Toll-Like Receptor, Interferon and Viruses. Microbiol Immunol. 48, 147-154 (2004)